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2e). A physiologically appropriate IgE concentration of 12.5 nM (Supplementary Fig. second) was pre-incubated with ligelizumab or omalizumab IgG in different concentrations. In arrangement Along with the ELISA info, we noticed weaker inhibition of IgE-binding to CD23 on RPMI8866 cells with ligelizumab than with omalizumab (Fig. 2f). Consequently, the two anti-IgE antibodies expose a qualitatively unique inhibition profile for the two IgE receptor pathways with ligelizumab being additional strong and more selective for inhibition of IgE binding to FcεRI.
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The mechanistic and useful profile with the therapeutic anti-IgE antibody ligelizumab differs from omalizumab